Unfortunately Windows doesn’t provide a simple way for you to
enable or disable automatically running CD-ROMs. I will show
you 2 ways, the manual and automatic way to disable autorun on
Windows.

There’s a trick where you can stop autorun CD in Windows by
pressing a key. Just press the SHIFT key and hold the key for a
while when you load a CD.
SHIFT key to disable autorun
This is also useful for U3 smart drives if you don’t want it to
automatically run the U3 launchpad.

To MANUALLY and permanently enable or disable automatically
running CD-ROMs, you must edit the registry:

1. Click Start, click Run, type regedit in the Open box, and
then press ENTER.

2. Locate and click the following registry key:
HKEY_LOCAL_MACHINE\System\CurrentControlSet\Services\CDRom

3. To disable automatically running CD-ROMs, change the Autorun
value to 0 (zero). To enable automatically running CD-ROMs,
change the Autorun value to 1.

Disable CD autoplay in Windows

4. Restart your computer.
Note: If you’d to re-enable CD autoplay but it doesn’t work,
you might want to check two other registry keys that can affect
this functionality. Make sure that both values is “0×00000095”
HKCU\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer
Value: NoDriveTypeAutoRun = 0×00000095

HKU\.DEFAULT\Software\Microsoft\Windows\CurrentVersion\Policies

\Explorer
Value: NoDriveTypeAutoRun = 0×00000095

Regards ,
Prasad R Suvarna